Elevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma

Autor:	Mingjie Yao, Weiquan Lu, Xiangmei Chen, Quanjun Lv, Yiwei Zhu, Xiaotong Yan, Xiangjun Qian, Lu Fengmin, Ling Zhang, Erjiang Zhao, Xiajie Wen
Rok vydání:	2019
Předmět:	0301 basic medicine Curative resection medicine.medical_specialty Multivariate analysis Apolipoprotein B biology business.industry medicine.disease Logistic regression Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine Cohort medicine biology.protein lipids (amino acids peptides and proteins) Pharmacology (medical) In patient Liver function business
Zdroj:	OncoTargets and Therapy. 12:1957-1964
ISSN:	1178-6930
DOI:	10.2147/ott.s192631
Popis:	Aims To date, curative resection remains to be the most optimal therapeutic choice of hepatocellular carcinoma (HCC), though the overall survival (OS) remains extremely unsatisfactory. To better manage the HCC patients, we evaluated the prognosis predicting values of apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) on the long-time survival of patients who underwent surgical treatment in this study. Methods A subgroup of 164 patients from our previously described follow-up cohort were enrolled in this study, of whom the pre-surgery ApoB and LDL-C measurements were available. They had been followed until January 2017, with a 19.5 months median survival time. The prognosis predicting values of serum ApoB, LDL-C, and other clinical variables were evaluated through Cox univariate and multivariate analyses, meanwhile, Kaplan-Meier analysis was conducted to obtain the OS curves. Results Pre-surgery ApoB was an independent prognosis predicting factor with HR as 1.396 (P=0.033), elevated ApoB was associated with worse postsurgery prognosis in HCC patients. Concordantly, Spearman's correlation analysis revealed that value of pre-surgery ApoB was to some extent correlated with tumor size (r=0.355, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7055bf089f19c6a16ca877aa5bec460a https://doi.org/10.2147/ott.s192631 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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