Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery
| Autor: | Thi Thuy Nga Tran, Tan Phuoc Nguyen, Thi Van Thi Tran, Xuan Nui Pham, Tuyet Nhung Pham |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Industrial and Manufacturing Engineering 0104 chemical sciences Chitosan chemistry.chemical_compound chemistry Drug delivery Curcumin Magnetic nanoparticles General Materials Science Electrical and Electronic Engineering Fourier transform infrared spectroscopy 0210 nano-technology Iron oxide nanoparticles Superparamagnetism Nuclear chemistry |
| Zdroj: | Advances in Natural Sciences: Nanoscience and Nanotechnology. 7:045010 |
| ISSN: | 2043-6262 |
| DOI: | 10.1088/2043-6262/7/4/045010 |
| Popis: | In this work anti-cancer drug curcumin-loaded superparamagnetic iron oxide (Fe3O4) nanoparticles was modified by chitosan (CS). The magnetic iron oxide nanoparticles were synthesized by using reverse micro-emulsion (water-in-oil) method. The magnetic nanoparticles without loaded drug and drug-loaded magnetic nanoparticles were characterized by XRD, FTIR, TG-DTA, SEM, TEM, and VSM techniques. These nanoparticles have almost spherical shape and their diameter varies from 8 nm to 17 nm. Measurement of VSM at room temperature showed that iron oxide nanoparticles have superparamagnetic properties. In vitro drug loading and release behavior of curcumin drug-loaded CS-Fe3O4 nanoparticles were studied by using UV-spectrophotometer. In addition, the cytotoxicity of the modified nanoparticles has shown anticancer activity against A549 cell with IC50 value of 73.03 μg/ml. Therefore, the modified magnetic nanoparticles can be used as drug delivery carriers on target in the treatment of cancer cells. |
| Databáze: | OpenAIRE |
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