Interconversion between Fenthion and Fenthion Sulfoxide in Goldfish, Carassius auratus

Autor:	Mayumi Yoshida, Shigeru Ohta, Tomoko Kadota, Shigeyuki Kitamura
Rok vydání:	1999
Předmět:	Oxidase test Fenthion biology Health Toxicology and Mutagenesis Metabolite Cytochrome P450 Sulfoxide Toxicology chemistry.chemical_compound Biochemistry chemistry Menadione biology.protein Microsome Aldehyde oxidase
Zdroj:	Journal of Health Science. 45:266-270
ISSN:	1347-5207 1344-9702
DOI:	10.1248/jhs.45.266
Popis:	The in vitro metabolism of fenthion, an insecticide, was examined in fish, focusing on the interconversion between fenthion and its sulfoxide (fenthion sulfoxide). When fenthion was incubated with hepatopancreas microsomes of goldfish, Carassius auratus, in the presence of NADPH, the oxidized metabolite, fenthion sulfoxide was formed, but not fenthion sulfone. The oxidase activity was inhibited by SKF 525-A, and partly by α-naphthylthiourea. In contrast, fenthion sulfoxide was reduced back to fenthion by the hepatopancreas cytosol of goldfish in the presence of 2-hydroxypyrimidine, an electron donor for aldehyde oxidase. The activity was markedly inhibited by menadione, an inhibitor for aldehyde oxidase. The interconversion appears to be mediated mainly by the cytochrome P450 system and aldehyde oxidase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6feb61623a9b861e9bf2b34ae53a7de9 https://doi.org/10.1248/jhs.45.266 Zobrazit plný text záznamu