Benzofuran-oxadiazole hybrids: Design, synthesis, antitubercular activity and molecular docking studies
| Autor: | P. V. Anantha Lakshmi, Sathish Kumar Boda, Veerabhadrayya S. Negalurmath, Mahantesha Basanagouda, Obelannavar Kotresh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Oxadiazole General Chemistry Pyrazinamide 010402 general chemistry biology.organism_classification 01 natural sciences In vitro 0104 chemical sciences chemistry.chemical_compound Design synthesis chemistry Mycobacterium tuberculosis H37Rv medicine Structure–activity relationship Benzofuran Mycobacterium phlei medicine.drug |
| Zdroj: | Chemical Data Collections. 19:100178 |
| ISSN: | 2405-8300 |
| DOI: | 10.1016/j.cdc.2019.100178 |
| Popis: | The fifteen benzofuran-oxadiazole derivatives 7(a-o) have been designed, synthesized, characterized and evaluated for preliminary antitubercular activity against Mycobacterium tuberculosis H37RV and Mycobacterium phlei. The structure activity relationship (SAR) results have shown the compounds with chlorine (7j, 7k) and bromine (7l, 7m) on benzofuran exhibit excellent activity. The highest activity of 7m superior to standard drug pyrazinamide was further supported by molecular docking results. The in vitro antitubercular experimental results and structure activity relationship studies were supported using molecular docking studies on these novel hybrids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect