Incidental focal colonic uptake on 18 F-FDG PET/CT studies

Autor: V. Gigirey, M. García Fontes, Omar Alonso, L. Servente
Rok vydání: 2018
Předmět:
Zdroj: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 37:15-19
ISSN: 2253-8089
DOI: 10.1016/j.remnie.2017.10.013
Popis: Objectives To assess the frequency of focal colonic uptake as an incidental observation in 18F-FDG PET/CT studies, and to correlate this finding with histopathological results. Material and methods A systematic analysis of 30 studies reporting focal colonic uptake out of a total of 3176 PET/CT studies with 18F-FDG was carried out. Patients with known colorectal neoplasia were excluded. The maximum standardized uptake values (SUVm) and the morphological findings provided by the CT were recorded. The studies were reported by a radiologist and a nuclear medicine physician. The findings were compared with endoscopy and pathology findings. Results Of the 30 patients with focal hypermetabolic lesions of the colon (0.94%), 15 were men and 15 were women with ages between 27 and 73 (mean 55 years). The reasons for PET/CT were bronchopulmonary cancer (4), breast cancer (4), tumor of unknown origin (4), melanoma (3), renal carcinoma (3), cervical neoplasia (2), adenocarcinoma of ovary (2), and others (8). Of the 23 colonoscopies performed, 10 patients (43.4%) had malignant lesions, 6 (26.1%) had pre-malignant lesions, and in 7 patients (30.4%) no lesion was identified or was benign. No endoscopy was performed on 7 patients for various reasons (patient refusal to perform the study, advanced oncological disease). An analysis was performed with the SUVm, with no statistically significant differences between malignant–premalignant lesions and benign lesions. Conclusions Focal uptake in the colon of 18F-FDG PET/CT has clinical relevance, especially when it is associated with morphological lesions on CT. As it may be a second tumor or a pre-malignant lesion, it is recommended that all focal uptake of the colon with or without abnormal CT be evaluated with endoscopy.
Databáze: OpenAIRE
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