Iron-induced oxidative rat liver injury after non-heart-beating warm ischemia is mediated by tumor necrosis factor α and prevented by deferoxamine
| Autor: | Gary P. Jeffrey, Ling Jun Mou, Wen Hua Huang, Bastiaan de Boer, Luc Delriviere, Xianwa Niu |
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| Rok vydání: | 2014 |
| Předmět: |
Transplantation
medicine.medical_specialty Hepatology business.industry medicine.medical_treatment Cold storage Liver transplantation medicine.disease_cause Malondialdehyde Lipid peroxidation Deferoxamine chemistry.chemical_compound Endocrinology chemistry Internal medicine Lactate dehydrogenase Immunology medicine Surgery Viaspan business Oxidative stress medicine.drug |
| Zdroj: | Liver Transplantation. 20:904-911 |
| ISSN: | 1527-6465 |
| Popis: | This study investigated iron-induced injury after warm ischemia in a non–heart-beating (NHB) rat liver model and the effects of deferoxamine (DFO). Livers from heart-beating (HB) rats or rats that were NHB for 60 minutes were stored in University of Wisconsin solution for 5 hours at 4°C [cold storage (CS)] and then were subjected to 2 hours of machine reperfusion (MRP) at 37°C. Three NHB groups were compared: (1) no DFO, (2) DFO 30 minutes before cardiac arrest and during CS and MRP, and (3) DFO during CS and MRP. Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) levels in the NHB perfusate were significantly elevated (P |
| Databáze: | OpenAIRE |
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