MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

Autor:	Lise Lotte Christensen, Kristian Q Hansen, Mads Rasmussen, Rikke Hagemann-Madsen, Kasper Thorsen, Peter Gibbs, Bodil Øster, Philippe Lamy, Claus L. Andersen, Marie Stampe Ostenfeld, Søren Laurberg, Kristina Byskov, Troels Schepeler, Karin Birkenkamp-Demtroeder, Anja Holm, Oliver M. Sieber, Heidi Tobiasen, Jan Lubinski, Torben F. Ørntoft
Rok vydání:	2013
Předmět:	Cancer Research Gene knockdown Pathology medicine.medical_specialty Colorectal cancer Cancer Cell cycle Biology medicine.disease Breast cancer Oncology Intestinal mucosa microRNA medicine Cancer research Gene silencing
Zdroj:	International Journal of Cancer. 133:67-78
ISSN:	0020-7136
DOI:	10.1002/ijc.28010
Popis:	Colorectal cancer (CRC) is one of the leading causes of cancer deaths in Western countries. A significant number of CRC patients undergoing curatively intended surgery subsequently develop recurrence and die from the disease. MicroRNAs (miRNAs) are aberrantly expressed in cancers and appear to have both diagnostic and prognostic significance. In this study, we identified novel miRNAs associated with recurrence of CRC, and their possible mechanism of action. TaqMan(®) Human MicroRNA Array Set v2.0 was used to profile the expression of 667 miRNAs in 14 normal colon mucosas and 46 microsatellite stable CRC tumors. Four miRNAs (miR-362-3p, miR-570, miR-148 a* and miR-944) were expressed at a higher level in tumors from patients with no recurrence (p
Databáze:	OpenAIRE
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