Evaluation of the immune memory response to routine HBV vaccine in Egyptian patients with Type 1 diabetes

Autor:	Mona M. Soliman, Eman Fathalla Gad, Samaher F Taha, Nahla M. Elsherbiny, Ragaa H. M. Salama, Esraa M Eloseily, Ghada A. Mohamed, Azza Abo Elfadl, Helal F Hetta
Rok vydání:	2020
Předmět:	Immune memory response Type 1 diabetes business.industry virus diseases 030209 endocrinology & metabolism medicine.disease digestive system diseases 03 medical and health sciences 0302 clinical medicine Virology Immunology medicine 030212 general & internal medicine business
Zdroj:	Future Virology. 15:215-222
ISSN:	1746-0808 1746-0794
Popis:	We aimed to evaluate the immune memory response to HBV vaccine in diabetic patients who had received the full HBV vaccination during infancy and to assess the need for booster doses. Blood samples were collected from children (93 diabetics and 105 controls) and university students (22 diabetics and 20 controls). Anti-HBs titer in serum and after in vitro stimulation of peripheral blood mononuclear cells with HBV vaccine was measured by ELISA. Diabetic groups had significantly lower anti-HBs levels after 10 years of the last HBV vaccine dose. The percentage of diabetic patients having protective anti-HBs titers was significantly lower than controls. In conclusion, diabetic patients had lower immune response to HBV vaccine over time, emphasizing the need for a booster dose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6dc2ada05d5aa2242a4984b292888b3e https://doi.org/10.2217/fvl-2019-0121 Zobrazit plný text záznamu