Renal Effects of Mandragora officinarum Leaf Extracts on Wistar Albino Rats
| Autor: | Dr. Chioma Don-Lawson, Dr. Oforibika, G. A |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Scholars International Journal of Chemistry and Material Sciences. 5:151-155 |
| ISSN: | 2617-6556 2616-8669 |
| Popis: | This study demonstrates the renal features of wistar albino rats exposed to Mandragora officinarum leaf extract. Twenty-four (24) rats were randomly divided into 4 groups labelled A, B, C and D and kept in a well-ventilated room. Group A served as control and these rats were treated with distilled water. Rats in the groups B, C, and D were treated with 3 different doses of the sample (1.5, 3.5 and 5.0mL/KgBW) respectively. Samples were administered once daily for 14 and 28days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. Serum urea and creatinine concentrations increased in a dose dependent manner at all durations of administration. This increase was significant for urea at the dose of 5.0ml/kgBW when administered for 14 days. This trend was present at all doses for 28 days of administration. Histology done showed normal kidney tissue architecture at all doses of 14days of administration. All doses in the 28 days group showed abnormalities of destroyed renal tubules, absent glomeruli and occluded bowman’s capsular spaces. This study demonstrates that long-term use of this leaf extract increases the risk of subacute kidney abnormalities. |
| Databáze: | OpenAIRE |
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