From biomimicry to bioelectronics: Smart materials for cardiac tissue engineering
Autor: | Olurotimi A. Bolonduro, Lauren D. Black, Akshita A. Rao, Breanna M. Duffy, Brian P. Timko |
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Rok vydání: | 2020 |
Předmět: |
Bioelectronics
Scaffold 3D bioprinting media_common.quotation_subject Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Smart material 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences law.invention Delivery methods Tissue engineering law General Materials Science Electrical and Electronic Engineering Biomimetics 0210 nano-technology Function (engineering) media_common |
Zdroj: | Nano Research. 13:1253-1267 |
ISSN: | 1998-0000 1998-0124 |
Popis: | Effective strategies in cardiac tissue engineering require matrices that recapitulate the mechanical, topographic and electrical cues present in the native extracellular matrix. In this review, we discuss recent efforts in materials science and nanotechnology to achieve functional three-dimensional (3D) scaffolds that modulate and monitor cardiac tissue function. We consider key design considerations, including choice of biopolymer matrix, cell sources, and delivery methods for eventual therapies. We then discuss how solid-state nanomaterials may be integrated within these systems to provide unique electrical and nanotopographic cues that improve electromechanical synchrony. We describe how these approaches may be extended to complex, spatially heterogeneous constructs using 3D bioprinting techniques. Finally, we describe how scaffold materials may be augmented with bioelectronic components to achieve hybrid myocardium that monitors or controls electrophysiological activity. Collectively, these approaches provide a framework for achieving cardiac tissues with tunable, rationally-designed functionalities. We discuss future prospects and remaining challenges for clinical translation. |
Databáze: | OpenAIRE |
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