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Background: The purpose of this study is to investigate the effects of derived neutrophil-lymphocyte ratio (dNLR), albumin-fibrinogen ratio (AFR) and albumin-AFR-dNLR score (ADS) on the prognosis of glioblastoma multiforme (GBM) patients.Patients and Methods: The clinical data of 142 GBM patients were retrospectively analyzed. Survival analyses were performed to assess the predictive role of ADS in GBM patients.Results: There were 142 patients enrolled in the present study. Among these patients, 58 were female, and 84 were male. The mean age at diagnosis was 55±13.78 years. The mean fibrinogen, albumin, AFR, and dNLR were 2.95±0.93g/L, 42.48±3.78g/L, 15.84±5.14 and 3.09±3.90, respectively. Fifty patients had ADS of 0, 53 had ADS of 1, 27 had ADS of 2 and 12 had ADS of 3. In univariate analysis, patients age≥60 years (HR: 1.912;95%CI:1.217-2.878, p=0.002), albumin ≥41.7g/L(HR: 0.614; 95%CI: 0.417-0.905, p=0.014), AFR ≥13.9(HR: 0.649; 95%CI:0.440-0.958, p=0.029), dNLR ≥3.3(HR: 1.609;95%CI:1.024-2.529, p=0.039), ADSConclusion: ADS, AFR, and dNLR are independent prognostic factors in patients with GBM. |
