A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable?

Autor: Constantin Potagas, Marina Katsari, Ioannis Zalonis, Elisabeth Andreadou, Marianthi Breza, Maria Anagnostouli, Maria-Eleftheria Evangelopoulos, C. Kilidireas, Erasmia Giogkaraki, Alia Hotary, Georgios Koutsis, Dimitrios Kasselimis
Rok vydání: 2020
Předmět:
Zdroj: Journal of Neurology. 267:1464-1475
ISSN: 1432-1459
0340-5354
DOI: 10.1007/s00415-020-09720-8
Popis: Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce. We aimed to investigate the cognitive 10-year course of a cohort of MS patients. 59 patients with clinically isolated syndrome (CIS) or relapsing–remitting (RR) MS were evaluated with Rao’s Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts. The proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline. This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving “dementia”.
Databáze: OpenAIRE
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