Ordered mesoporous molecular sieves as active catalyts for the synthesis of 1,4-dihydropyridine derivatives
| Autor: | Rosa M. Martín-Aranda, Vanesa Calvino-Casilda |
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| Rok vydání: | 2020 |
| Předmět: |
1 4 dihydropyridine derivatives
Nanotechnology 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Molecular sieve 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry High surface area Organic synthesis Fine chemical Thermal stability 0210 nano-technology Mesoporous material |
| Zdroj: | Catalysis Today. 354:44-50 |
| ISSN: | 0920-5861 |
| Popis: | Research on heterocyclic compounds with biological and pharmacological activity continues to arouse great interest. The study of 1,4-dihydropyridines (1,4-DHPs) is of particular interest in the pharmaceutical field due to their important applications as calcium channel antagonists for the treatment of heart diseases. The implementation of novel heterogeneous catalysts to optimize Hantzsch synthesis, such as ordered mesoporous molecular sieves, is an efficient and eco-friendly proposal that still requires a lot of work. The remarkable features of ordered mesoporous molecular sieves, such as high surface area, tailored porosity, chemical and thermal stability, among others, turn these materials into powerful solid catalysts capable of selectively leading the synthesis of 1,4-DHPs. In addition, the combination of ordered mesoporous molecular sieves and process intensification for the synthesis of 1,4-DHP derivatives is still a research field in development. Therefore, promote greener methodologies in the synthesis of 1,4-DHPs that can be extended to any organic synthesis in fine chemical production is an important goal yet to be achieved. |
| Databáze: | OpenAIRE |
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