Formation of Human T Cell Mucosal Resident Memory Starts in Early Life with the Intestines
| Autor: | Thomas Connors, Puspa Thapa, Margot C Yopes, Rebecca S Guyer, Mei Mei Li, Mark E Snyder, Donna L Farber |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 202:67.21-67.21 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.202.supp.67.21 |
| Popis: | Memory T cells are essential for optimal protection from previously encountered pathogens. Immune responses in infants lack the benefit of memory and are intrinsically distinct from those in adults. Early life adaptive immune responses have been characterized by increased generation of terminal effector subsets with decreased production of long lived memory. Here we investigate the origin of memory T cells utilizing flow cytometry and immunohistochemistry to characterize proportions and localization of T cell subsets in mucosal (intestine/lung) tissue from infant organ donors (n=12). At birth lung T cells are predominantly naïve and localized to the interstitium of the airways with memory accumulating over the first year of life. In contrast, significant proportions of memory phenotype T cells can be found in the lamina propria and intraepithelial layer of the intestine shortly after birth along with naïve cells. Effector memory subsets could be detected in robust proportions, highest in the jejunum, from 3 organ donors all less than 8 days of age. Additionally these memory T cells displayed high levels of canonical resident memory markers (CD69 and CD103). We conclude that mucosal tissues are host to naïve cells which cannot be attributable to circulating populations and that memory subsets are generated within these mucosal sites early in life. Importantly T cells in the youngest donors (ages 0–8 days) displayed resident memory phenotypes raising the possibility of prenatal development of adaptive memory responses populating the intestine. These results warrant additional investigation to determine the persistence and functionality of these subsets and emphasize the importance of the intestine to early life adaptive immunity. |
| Databáze: | OpenAIRE |
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