Phytochemical screening, hepatoprotective and antioxidant effects of leaf extracts of Zapoteca portoricensis
| Autor: | K. N. Agbafor, Emmanuel Iroha Akubugwo, M. E. Ogbanshi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Antioxidant
Traditional medicine Vitamin C biology medicine.medical_treatment Malondialdehyde biology.organism_classification Terpenoid Superoxide dismutase chemistry.chemical_compound chemistry Phytochemical Biochemistry Carbon tetrachloride biology.protein medicine Pharmacology (medical) Zapoteca portoricensis |
| Zdroj: | Advances in Biological Chemistry. :35-39 |
| ISSN: | 2162-2191 2162-2183 |
| DOI: | 10.4236/abc.2014.41006 |
| Popis: | Fresh leaves of Zapoteca portoricensis are used in Eastern Nigeria for management/treatment of various disorders without any scientific basis. Hepatoprotective and antioxidant properties in albino rats, and phytochemical composition of distilled water and ethanol leaf extracts were studied. Fifty-five animals were placed in eleven groups (A-K) of five in each. Different doses (100, 200, 400 and 600 mg/kg body weight) of the extracts, 20 mg/kg body weight of vitamin C (standard antioxidant) and distilled water were orally administered to groups A-H, I and J-K respectively for six consecutive days. On the seventh day, 2.5 ml/kg body weight of carbon tetrachloride (CCl4) was given intraperitoneally to groups A-J, while group K received distilled. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were used to study hepatoprotective effect. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels in the liver were monitored to assess antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, tannins, saponins, flavonoids, anthraquinones, terpenoids and cardiac glycosides in the extracts. Pretreatment of the rats with the extracts produced a significant decrease (p |
| Databáze: | OpenAIRE |
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