| Autor: |
L.B. Rametti, H.S. Bradlow |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
IFAC Proceedings Volumes. 15:1229-1234 |
| ISSN: |
1474-6670 |
| DOI: |
10.1016/s1474-6670(17)63165-3 |
| Popis: |
It is proposed to use an automatated feedback control system to solve the clinical problems associated with the achievement of muscle relaxation during surgical procedures. Due to the variability between individuals a 1 self-tuning' control system would" be required. This paper deals with the problems of determining a suitable model structure and model order for the human response to the muscle relaxant drug curare (or d-Tubocurarine) for use in such a self-tuning control loop. We present a formalism based on linear compartmental theory, and show by examining its structural identiflability how it can be commpared with existing clinical models. We then use off-line non-linear least-squares fitting and the general linear test to obtain a simple bi-compartment model structure, which we show by simulation to be suitable for control purposes and an improvement over existing models. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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