| Autor: | T. L. D'yakonova |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Physiology
Metabotropic glutamate receptor 6 Glutamate receptor Snail Biology Helix lucorum biology.organism_classification Inhibitory postsynaptic potential Serotonergic Biochemistry biology.animal Excitatory postsynaptic potential NMDA receptor Neuroscience Ecology Evolution Behavior and Systematics |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 38:202-210 |
| ISSN: | 0022-0930 |
| DOI: | 10.1023/a:1016514606077 |
| Popis: | This work is a continuation of the study on transmitter regulation of the serotoninergic system activity in the brain of the edible snail Helix lucorum, in which serotonin and NO donors have been shown to excite serotoninergic neurons from various snail ganglia (more than 60 of them were studied) and synchronize their activity by activation of the synchronous synaptic inputs. In the current work, it has been shown that glutamate, on the contrary, has an inhibitory and desynchronizing action on the same serotonin-containing neurons by suppressing their own activity and switching off the synchronous synaptic inputs. In the same neurons, another glutamate receptor agonist, NMDA, has a pronounced excitatory effect and activates the synchronous synaptic inputs. The glutamate effects are NO-dependent: the NO donor sodium nitroprusside decreases, switches off entirely, or transforms the glutamate inhibitory effect into the excitatory one. A possible mechanism of interaction of serotonin, glutamate, and NO in regulation of the snail serotoninergic system activity is discussed. |
| Databáze: | OpenAIRE |
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