Synthesis of new 2-substituted 6,7-dimethoxy-1-(methylcarbamoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolines

Autor:	E. A. Markaryan, A. A. Aghekyan, G. G. Mkryan
Rok vydání:	2013
Předmět:	chemistry.chemical_compound chemistry Tetrahydroisoquinoline Organic Chemistry Combinatorial chemistry
Zdroj:	Russian Journal of Organic Chemistry. 49:1632-1636
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428013110122
Popis:	New 2-(heterylmethyl) derivatives were synthesized from 6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide and heterylmethyl chlorides. The reactions of 2-chloroacetyl-substituted tetrahydroisoquinoline with versatile secondary amines and heterylthiols afforded the corresponding 2-aminoacetyl and 2-(heterylsulfanylacetyl) derivatives of tetrahydroisoquinoline series.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69cfd55514dc7b362c11a4f5aebbc4c6 https://doi.org/10.1134/s1070428013110122 Zobrazit plný text záznamu Plný text ve formátu PDF