Screening von modifizierten Polyethylenoberflächen für das Tissue-Engineering von Chondrozyten

Autor:	J. Jamali, J. Vogel, E. Röpke, I. Schön, Marc Bloching, A. Berghaus
Rok vydání:	2007
Předmět:	Autologous cell chemistry.chemical_compound Materials science Otorhinolaryngology Tissue engineering chemistry Biocompatibility Life time Surface modification Collagen coating Polyethylene Biocompatible material Biomedical engineering
Zdroj:	Laryngo-Rhino-Otologie. 86:37-43
ISSN:	1438-8685 0935-8943
DOI:	10.1055/s-2006-945025
Popis:	Background Reconstructive surgery needs high requirements of substitutes for cartilages. The availability of autologous material is limited. The use of implants can cause inflammatory reactions. Therefore the biocompatibility of porous polyethylene should be improved by masking the synthetic surface with autologous cells. The polyethylene surface was functionalized by collagen, in order to enhance the contact between polyethylene and the surrounding cells. Methods The modified surfaces were characterized and tested by an in vitro screening with primary human chondrocytes. Results The modification of polyethylene surfaces by collagen coating increased the life time of chondrocytes growing at this surface. The effect was independent of the former functionalization. Conclusions It is possible to cultivate chondrocytes on polyethylene surfaces. The results have to be proven in a long-term animal experimental study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69cb2a6fea88018c08497f21c5e01c11 https://doi.org/10.1055/s-2006-945025 Zobrazit plný text záznamu