Task-Specific Hypoactivation in Prefrontal and Temporoparietal Brain Regions During Motor Inhibition and Task Switching in Medication-Naive Children and Adolescents With Attention Deficit Hyperactivity Disorder
| Autor: | Brian Toone, Katya Rubia, Mick Brammer, Anna B. Smith, Eric Taylor |
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| Rok vydání: | 2006 |
| Předmět: |
Task switching
medicine.medical_specialty Cognitive flexibility Audiology medicine.disease behavioral disciplines and activities Brain mapping Functional imaging Psychiatry and Mental health Go/no go mental disorders medicine Attention deficit hyperactivity disorder Psychology Prefrontal cortex Neuroscience Stroop effect |
| Zdroj: | American Journal of Psychiatry. 163:1044-1051 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.2006.163.6.1044 |
| Popis: | Objective: A relatively small number of functional imaging studies of attention deficit hyperactivity disorder (ADHD) have shown abnormal prefrontal and striatal brain activation during tasks of motor response inhibition. However, the potential confound of previous medication exposure has not yet been addressed, and no functional imaging study exists to date on medication-naive children and adolescents with ADHD. The aim of this study was to investigate the neural substrates of a range of motor and cognitive inhibitory functions in a relatively large group of children and adolescents with ADHD who had never previously been exposed to medication. Method: Nineteen boys with ADHD and 27 healthy age- and IQ-matched boys underwent functional MRI to compare brain activation during performance of tasks that assessed motor response inhibition (go/no go task), cognitive interference inhibition (motor Stroop task), and cognitive flexibility (switch task). Results: Boys with ADHD showed decreased activation in the l... |
| Databáze: | OpenAIRE |
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