Hemostatic Disorder of Uremia: The Platelet Defect, Main Determinant of the Prolonged Bleeding Time, Is Correlated with Indices of Activation of Coagulation and Fibrinolysis
| Autor: | M Pérez, O Panes, B Muñoz, Diego Mezzano, Jaime Pereira, Sergio Mezzano, F González, Eduardo Aranda, Rodrigo Tagle, S Thambo, P. Barja, P Downey |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry medicine.medical_treatment Hematology Fibrinogen Endocrinology Von Willebrand factor Coagulation Bleeding time Internal medicine Hemostasis Fibrinolysis biology.protein Medicine Platelet Platelet activation business medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 76:312-321 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1650576 |
| Popis: | SummarySeveral parameters of primary hemostasis and markers of activation of coagulation and fibrinolysis were measured in 48 patients with severe (creatinine clearance High levels of plasma thrombin-antithrombin complexes (TAT), prothrombin fragment F1+2, fibrinogen and factor VIIc were observed in patients with CRF, as described in prethrombotic states. Plasmin-antiplasmin complexes (PAP), fibrinogen and fibrin degradation products (FgDP, FnDP) were significantly increased, and the activity of plasminogen activator inhibitor (PAI-1) was slightly reduced, denoting an activation of fibrinolysis.A negative correlation was found between platelet levels of ATP and ADP with plasma TAT, F1+2 and PAP. Furthermore, plasma PAI-1 activity was negatively correlated with the BT and was lower in patients with prolonged BT as compared with controls and patients with normal BT. These links between primary hemostasis and activation of coagulation and fibrinolysis suggest that increased intravascular generation of thrombin and/or plasmin is an important mediator of the defects in primary hemostasis, prolongation of the BT and, probably, bleeding in CRF. |
| Databáze: | OpenAIRE |
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