A Weakened Geomagnetic Field: Effects on Genomic Transcriptiln Activity, Learning, and Memory in Drosophila Melanogaster
| Autor: | E. V. Savvateeva-Popova, Sergei Viktorovich Surma, V. S. Pronikov, B. F. Shchegolev, A. V. Medvedeva, Ekaterina A. Nikitina, M. S. Gerasimenko |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
LIMK1 Gene Genetics biology General Neuroscience Mutant Actin remodeling Cognition biology.organism_classification Genome 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Drosophila melanogaster Drosophila 030217 neurology & neurosurgery Genomic organization |
| Zdroj: | Neuroscience and Behavioral Physiology. 48:796-803 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-018-0632-2 |
| Popis: | Neurodegenerative diseases result from a complex interaction between unfavorable environmental factors and the individual characteristics of the genome which predispose to disease development. Drosophila provides a suitable system for studies of the relationship between genomic organization and chromosomal architecture producing cognitive impairments. We present here the results of complex investigations of the effects of attenuation of the geomagnetic field (by screening) on genomic transcriptional activity, learning ability, and the formation of intermediate-term memory in Drosophila melanogaster. In this stress, a relationship was seen between modifications to transcriptional activity and the structure of the LIMK1 gene – a key enzyme in the actin remodeling cascade. Impairments to intermediate-term memory were seen on exposure to a weak static magnetic field in Canton-S wild-type flies. Conversely, this same stress restored learning ability and memory formation in agnts3 mutants. |
| Databáze: | OpenAIRE |
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