Deciphering General Characteristics of Residues Constituting Allosteric Communication Paths

Autor:	Anirban Banerji, Andrzej Kloczkowski, Irina A. Buhimschi, Girik Malik, Maksim Kouza
Rok vydání:	2019
Předmět:	Computer science Mechanism (biology) Allosteric regulation Posttranslational modification Protein activity Computational biology
Zdroj:	Bioinformatics and Biomedical Engineering ISBN: 9783030179342 IWBBIO (2)
DOI:	10.1007/978-3-030-17935-9_23
Popis:	Allostery is one of most important processes in molecular biology by which proteins transmit the information from one functional site to another, frequently distant site. The information on ligand binding or on posttranslational modification at one site is transmitted along allosteric communication path to another functional site allowing for regulation of protein activity. The detailed analysis of the general character of allosteric communication paths is therefore extremely important. It enables to better understand the mechanism of allostery and can be used in for the design of new generations of drugs.
Databáze:	OpenAIRE
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