Lactose intolerance and its association with the exogamy degree among the population of eastern Ukraine
| Autor: | V. V. Borozenets, V. O. Babalian, S. M. Mazniakov, O. M. Fedota, N. G. Puzik |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0303 health sciences education.field_of_study Lactose intolerance business.industry Exogamy Population medicine.disease 01 natural sciences Degree (temperature) 03 medical and health sciences Medicine business education Association (psychology) 030304 developmental biology 010606 plant biology & botany Demography |
| Zdroj: | Faktori eksperimental'noi evolucii organizmiv. 24:249-253 |
| ISSN: | 2415-3826 2219-3782 |
| DOI: | 10.7124/feeo.v24.1110 |
| Popis: | Aim. The aim of our study was to evaluate the relationship between exogamy degree and lactose assimialation among the population of Eastern Ukraine in the Kharkiv region. Methods. The analysis included information on consumption and assimilation of milk and dairy products by 733 people aged from 14 to 79 years were. Statistical analysis included Shapiro-Wilk test, Pearson fitting (χ2) criterion and Spearman’s correlation analysis. Results. The lactose tolerance (LT) phenotype was found in 69.5%, whereas lactose intolerance (LI) – in 8.8% (from 3.5% to 24.1% in different age groups). In the age group 30-39 years: LI frequency was 24.1% being 2.5-6 times higher than in other groups. The exogamy degree of parents (EDP) showed in the group aged from 30 to 39 years the first EDP was 15.4%, being 1.4-2.5 times less (p = 0,05) than in other groups. Among people with bone marrow disorders the proportion of people with the first and second EDP was 60.9%, being 2.1 to 6.0 times higher than in other groups. Reduced EDP or increased inbreeding level causes the similarity of the chromosomes and affects the density of contact points between them during meiosis, level of recombination can be increased and associated with multifactorial traits. Conclusions. The results can be explained by the effect of the inbreeding level reduction in the presence of a high level of exogamy of parents, which causes high genetic diversity. Keywords: lactose intolerance, lactose tolerance, exogamy degree of parents, single nucleotide polymorphisms 13910C-T and 22018G-A, gene МСМ6. |
| Databáze: | OpenAIRE |
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