Hypothalamic Circuits Responsive to Ghrelin: Regulation by Leptin and Insulin
| Autor: | S. L. Dickson, A. K. Hewson, Loraine Y.C. Tung |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Kidney Leptin receptor Insulin medicine.medical_treatment Leptin digestive oral and skin physiology Biology Endocrinology medicine.anatomical_structure Hypothalamus Placenta Internal medicine medicine Ghrelin Rat Stomach hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance ISBN: 9788847021709 |
| DOI: | 10.1007/978-88-470-2085-6_11 |
| Popis: | Since its discovery in 1999 (Kojima et al., 1999), ghrelin has emerged as a potentially important circulating hunger-inducing peptide (Wren et al., 2001a; Cummings et al., 2001). It was isolated from the oxyntic glands of the rat stomach (Kojima et al., 1999) and this appears to be the major source of circulating ghrelin as levels are reduced by 80% following gastrectomy (Dordonville de la Cour et al., 2001). Ghrelin mRNA has also been detected in a number of other organs, including the pituitary (Korbonits et al., 2001), hypothalamus (Kojima et al., 1999), kidney (Mori et al., 2000), bowel (Date et al., 2000) and placenta (Gualillo et al., 2001). |
| Databáze: | OpenAIRE |
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