Prognostic Value for Parameters of the Hemostasis System during Parvovirus Infection of Carnivores
| Autor: | E. S. Baruzdina, E. N. Soboleva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Prothrombin time medicine.medical_specialty medicine.diagnostic_test Chemistry 010604 marine biology & hydrobiology Parvovirus infection Thrombin time Fibrinogen medicine.disease 01 natural sciences Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology Internal medicine Hemostasis medicine Platelet Mean platelet volume 010606 plant biology & botany medicine.drug Partial thromboplastin time |
| Zdroj: | Russian Agricultural Sciences. 45:487-491 |
| ISSN: | 1934-8037 1068-3674 |
| DOI: | 10.3103/s1068367419050021 |
| Popis: | —Prognostic significance of the hemostasis system’s parameters in dogs with parvovirus infection has been evaluated. Blood test results of dead (n = 4) and surviving dogs (n = 11) on the third and fifth day of illness at 2–6-months of age were compared with each other and with results from the blood test of healthy dogs in the control group (n = 10). By the third day of the disease, as markers of an unfavorable prognosis, one can distinguish a decrease in platelet count to 285.97 ± 14.84 × 109/L, an increase in the average platelet volume to 8.5 ± 1.7 fl, and platelet survival time (PST) to 0.53 ± 0.02%, summing up of the platelet aggregation index with ADP induction aggregators to 131.67 ± 9.28% and ristomycin to 127.77 ± 14.71%, a decrease in disaggregation with ADP aggregation inducers to 1.03 ± 1.03% and ristomycin to 0.08 ± 0.08%, an increase in the amount of fibrinogen to 5.2 ± 0.49 g/L and soluble fibrin-monomer complexes to 12.97 ± 1.15 mg/100 mL with a decrease in antithrombin activity to 105.3 ± 3.16%. By the fifth day of illness, the risk of death is associated with such parameters as a progressive decrease in platelet count to 227 ± 15.64 × 109/L with a decrease in the average platelet volume to 5.5 ± 1.2 fl as well as PST to 0.21 ± 0.03% with a summing platelet aggregation index with ADP aggregation inducers to 31.67 ± 12.03%, with collagen to 15.53 ± 4.26%, and ristomycin to 14.8 ± 5.6%; a decrease in disaggregation with ADP by 81%, with collagen by 77%, and with ristomycin by 98.7%; an increase in prothrombin time from 14.17 ± 0.24 to 18.5 ± 2.9 s, thrombin time from 9.07 ± 0.58 to 15.3 ± 2.08 s, and activated partial thromboplastin time from 18.03 ± 1.54 to 26.37 ± 1.57 s as well as soluble fibrin-monomer complexes to 17.3 ± 1.17 mg/100 mL; a decrease in the amount of fibrinogen to 2.73 ± 0.89 g/L and antithrombin activity to 88.63 ± 14.93%. |
| Databáze: | OpenAIRE |
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