Aging Selectively Attenuates L‐Type Calcium Currents in Resistance Coronary Arteries

Autor:	Mohammed O. Hassan, Abdul Aleem Khan, Fathi Mansour, Sulayma Albarwani
Rok vydání:	2015
Předmět:	medicine.medical_specialty F344 rats chemistry.chemical_element Calcium medicine.disease Biochemistry Coronary arteries Coronary artery disease medicine.anatomical_structure Endocrinology chemistry Smooth muscle Internal medicine Genetics medicine Molecular Biology Biotechnology
Zdroj:	The FASEB Journal. 29
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.29.1_supplement.644.3
Popis:	The current density of L-type voltage-gated calcium (L-VGC) channels was reported to be inversely proportional to the diameter of coronary arteries. Since aging is a major risk factor for coronary artery disease, we investigated if the above relationship is altered with aging. Smooth muscle cells were isolated from coronary arteries of young (3-4 months) and old (22-26 months) male F344 rats. Whole-cell L-VGC currents were recorded using 10 mM Ba2+ as charge carrier from small (˂100µm) and large (250 to 400 µm) diameter arteries. Student's t-test was used to compare peak inward current densities (pA/pF; mean± S.E.M) between young and old arteries of similar size and the 2-way ANOVA was used to compare all four groups (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::687966075b0f738ab0ea4fa2ce294d72 https://doi.org/10.1096/fasebj.29.1_supplement.644.3 Zobrazit plný text záznamu Plný text