Idiopathic bile acid malabsorption: qualitative and quantitative clinical features and response to cholestyramine
| Autor: | Kieran Moriarty, H. J. Testa, Richard Liston, L. Sinha |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Cholestyramine Hepatology Bile acid medicine.drug_class business.industry medicine.medical_treatment digestive oral and skin physiology Gastroenterology Bile acid malabsorption Chronic diarrhoea medicine.disease chemistry.chemical_compound Diarrhea chemistry Internal medicine medicine Pharmacology (medical) medicine.symptom SeHCAT business Irritable bowel syndrome medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 12:839-844 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.1998.00388.x |
| Popis: | Background: Idiopathic bile acid malabsorption is a poorly recognized cause of chronic diarrhoea. The SeHCAT (75Selenium HomotauroCholic Acid Test) can accurately diagnose this condition. Aim: To identify patients with idiopathic bile acid malabsorption, to describe their clinical features, both qualitatively and quantitatively, and to assess the response to cholestyramine. Method: Idiopathic bile acid malabsorption was considered in all patients complaining of chronic diarrhoea. They were included in the study if their SeHCATs were positive ( 200 g/day) and three had steatorrhoea. Conclusions: Idiopathic bile acid malabsorption, once suspected, especially by documenting true ‘large volume’ watery diarrhoea or steatorrhoea, is easily diagnosed and response to therapy is often very good. There is often a previous history of gastrointestinal infection and this condition should be considered in patients with chronic diarrhoea of undetermined origin, especially before they are labelled as having irritable bowel syndrome. |
| Databáze: | OpenAIRE |
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