Reproducible automated breast density measure with no ionizing radiation using fat-water decomposition MRI
| Autor: | Jie Ding, Marilyn T. Marron, Maria I. Altbach, Chuan Huang, Yi Gao, Denise J. Roe, Betsy C. Wertheim, Alison Stopeck, Cynthia A. Thomson, Jean Philippe Galons, Patricia A. Thompson, Gertraud Maskarinec, Fang Wang |
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| Rok vydání: | 2018 |
| Předmět: |
education.field_of_study
Reproducibility business.industry Intraclass correlation Concordance Population computer.software_genre medicine.disease Pearson product-moment correlation coefficient 030218 nuclear medicine & medical imaging 03 medical and health sciences symbols.namesake 0302 clinical medicine Breast cancer Voxel 030220 oncology & carcinogenesis symbols Medicine Radiology Nuclear Medicine and imaging Stage (cooking) business education Nuclear medicine computer |
| Zdroj: | Journal of Magnetic Resonance Imaging. 48:971-981 |
| ISSN: | 1053-1807 |
| DOI: | 10.1002/jmri.26041 |
| Popis: | BACKGROUND Increased breast density is a significant independent risk factor for breast cancer, and recent studies show that this risk is modifiable. Hence, breast density measures sensitive to small changes are desired. PURPOSE Utilizing fat-water decomposition MRI, we propose an automated, reproducible breast density measurement, which is nonionizing and directly comparable to mammographic density (MD). STUDY TYPE Retrospective study. POPULATION The study included two sample sets of breast cancer patients enrolled in a clinical trial, for concordance analysis with MD (40 patients) and reproducibility analysis (10 patients). FIELD STRENGTH/SEQUENCE The majority of MRI scans (59 scans) were performed with a 1.5T GE Signa scanner using radial IDEAL-GRASE sequence, while the remaining (seven scans) were performed with a 3T Siemens Skyra using 3D Cartesian 6-echo GRE sequence with a similar fat-water separation technique. ASSESSMENT After automated breast segmentation, breast density was calculated using FraGW, a new measure developed to reliably reflect the amount of fibroglandular tissue and total water content in the entire breast. Based on its concordance with MD, FraGW was calibrated to MR-based breast density (MRD) to be comparable to MD. A previous breast density measurement, Fra80-the ratio of breast voxels with |
| Databáze: | OpenAIRE |
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