Gymnemic acid, a potent antidiabetic agent protects skeletal muscle from hyperglycemia mediated oxidative stress and apoptotic events in High fat and High fructose diet fed adult rats
| Autor: | Lakshmi Narasimhan Chakrapani, Bhavani Tamilarasan, Porkodi Karthikeyan, Kalaiselvi Periandavan, Pughazhendi Kannan, Thangarajeswari Mohan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Antioxidant biology 010405 organic chemistry medicine.medical_treatment Glucose uptake Skeletal muscle Type 2 diabetes 010402 general chemistry medicine.disease biology.organism_classification medicine.disease_cause 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Endocrinology medicine.anatomical_structure Insulin resistance chemistry Internal medicine Gymnemic acid medicine Gymnema sylvestre General Pharmacology Toxicology and Pharmaceutics Oxidative stress |
| Zdroj: | International Journal of Research in Pharmaceutical Sciences. 11:1526-1538 |
| ISSN: | 0975-7538 |
| DOI: | 10.26452/ijrps.v11i2.2029 |
| Popis: | Type 2 diabetes is delineated by impaired metabolic flexibility, and intramyocellular lipid accumulation, causing insulin resistance, particularly in skeletal muscle by reducing insulin-stimulated glucose uptake. High-fat diet and high fructose (HFD and HF) administration in rodents bestows a model for hyperlipidemia, insulin resistance, and Type 2 diabetes. The current study is focused on elucidating the role of Gymnemic acid in combating hyperglycemia mediated oxidative stress and apoptotic events in the skeletal muscle of HFD and HF induced Type 2 diabetes in Wistar albino rats by boosting antioxidant defense system. Gymnemic acid, a saponin of triterpene glycoside contained in leaves of Gymnema Sylvestre, has potent anti-diabetic properties. Treatment with Gymnemic acid restored the antioxidant status (Gpx, SOD, CAT, GR, Vit C & Vit E) with significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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