Role of salvage chemotherapy with topotecan and cisplatin in patients with paclitaxel- and platinum-resistant recurrent ovarian or primary peritoneal cancer: A phase II pilot study

Autor: Sharad A. Ghamande, M.Steven Piver
Rok vydání: 1999
Předmět:
Zdroj: Journal of Surgical Oncology. 72:162-169
ISSN: 1096-9098
0022-4790
DOI: 10.1002/(sici)1096-9098(199911)72:3<162::aid-jso9>3.0.co;2-0
Popis: Background and Objectives We assessed the role of salvage chemotherapy with topotecan and cisplatin in patients with platinum- and paclitaxel-resistant advanced and recurrent ovarian or primary peritoneal cancer, based on the reported in vivo and in vitro synergism between these two drugs. Methods Twenty patients were entered in this phase II trial from November 1997 to November 1998. They received cisplatin at 50 mg/m2 on day 1 with topotecan at 0.6 mg/m2 from day 1 to 5 every 28 days. In 70% of patients (14/20), this combination represented at least a third line of therapy. Results A clinical response rate of 13.3% (two partial responses) was obtained in the 15 patients with evaluable disease. Sixty percent of patients (9/15) had stable disease and 26.7% (4/15) had progression. The median progression-free interval and survival were 4 months and 7 months, respectively. The 20 patients evaluable for toxicity received a mean of four chemotherapy cycles. Dose reductions were required in 45% of patients despite the administration of growth factors. The major dose-limiting toxicity was a 50% occurrence (10/20) of grade 4 thrombocytopenia and 30% (6/20) grade 4 neutropenia. There was one septic death. Conclusions These data suggest that combination therapy with topotecan and cisplatin has minimal activity in platinum- and paclitaxel-resistant advanced and recurrent ovarian or primary peritoneal cancer at the doses utilized in this trial. J. Surg. Oncol. 1999;72:162–166. © 1999 Wiley-Liss, Inc.
Databáze: OpenAIRE
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