INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLOXACIN GRANULES AND TABLETS

Autor:	Zuhaeir Osman, Nemat S. Adam, Hassan A. Hassan, Abubakr O. Nur
Rok vydání:	2019
Předmět:	Pharmacology Central composite design Chemistry Hausner ratio Granule (cell biology) Pharmaceutical Science Friability Bulk density Screening design medicine Dissolution testing Food science Norfloxacin medicine.drug
Zdroj:	International Journal of Pharmacy and Pharmaceutical Sciences. :71-79
ISSN:	0975-1491 2656-0097
Popis:	Objective: To investigate the possible individual and joined influences that binding solution concentration, drying temperature and drying duration might have on the physiochemical attributes of granules and tablets using norfloxacin as a model drug. Methods: According to implemented 23 central composite designs, each of the investigated variables were examined at 5 different levels through different 16 formulation runs. For each formulation, obtained granules were qualified for their bulk density, tap density, Hausner ratio, percent of fine and drug content properties whereas the respective tablets were evaluated for their weight variation, drug content, friability, hardness, disintegration, and drug dissolution attributes. Results: Indicated that concentration of binder solution, as compared to drying temperature and drying duration, measured more profound influences on granules' tap density, Hausner ratio, % fine and drug content either through its individual linear and quadratic effects or through its joint effect with drying durations (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::66ff66fe898fe35981eac253236517ed https://doi.org/10.22159/ijpps.2019v11i10.17612 Zobrazit plný text záznamu