| Autor: |
Frederic Pilard, Annaig Ozier, Marielle Sabatini, Claire Bon, Mohammed Aliati, Marc Sapene, Cécilia Nocent-Ejnaini, Jean Michel Dupis, L. Falque, Mathieu Molimard, A. Prudhomme, Jean Moinard, Frédéric Le Guillou, Marie Line Quinquenel, Chantal Raherison-Semjen, Xavier Demant, Remi Veillon, Leo Grassion, Maeva Zysman, Laurent Nguyen, J. Casteigt, Mohammed Staali, A. Bernady, Esther Iglesias, Emmanuel Monge, Christophe Roy, Emilie Berteaud, Laura Petrov, Elodie Blanchard, Yannick Daoudi, El-hassane Ouaalaya, Julie Macey |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Epidemiology. |
| DOI: |
10.1183/13993003.congress-2020.1435 |
| Popis: |
The main factors that increase the mortality risk of COPD patients are age, comorbidities and the severity of airflow obstruction. This study aimed to validate the clinically relevant COPD phenotypes found by Burgel P-R et al [1] and analyzed their impact on 5-year mortality in the PALOMB cohort. COPD patients (post-BD FEV1/FVC 2,653 patients (66 years old, 64.27% males) were included. Application of the CART-based algorithm to Palomb cohort confirmed that it identified 5 COPD phenotypes with different clinical characteristics. In addition: The high proportion of FEV1 decline (≥100 ml/yr) belongs to phenotype 1 and 4; the majority of patients in these phenotypes were under oxygen therapy and they were associated with higher rates of exacerbation, lung cancer, anxiety and depression. These results confirmed the identification of five clinically relevant COPD phenotypes. A novel finding of this study is that FEV1 decline, frequency of exacerbations and other comorbidities were associated with the more severe phenotypes. Fundings: Bordeaux Univ Foundation, Novartis, Isis Medical, GSK, BI, Chiesi. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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