Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

Autor:	Dereje A. Negatu, Rubén González del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S. Ganapathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Rok vydání:	2023
Předmět:	Pharmacology Infectious Diseases Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 67
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.01459-22
Popis:	The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6668d4f8f3c6b25dd1c8741fce5cef2b https://doi.org/10.1128/aac.01459-22 Zobrazit plný text záznamu