Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models
| Autor: | Beate Winner, Johanna Kaindl |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Neurodegeneration Transdifferentiation Biology medicine.disease Embryonic stem cell 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genome editing Autism spectrum disorder Precursor cell medicine Stem cell Induced pluripotent stem cell Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioral Neurogenomics ISBN: 9783030312640 |
| Popis: | Human pluripotent stem (PS) cells are a relevant platform to model human-specific neurological disorders. In this chapter, we focus on human stem cell models for neuropsychiatric disorders including induced pluripotent stem (iPS) cell-derived neural precursor cells (NPCs), neurons and cerebral organoids. We discuss crucial steps for planning human disease modeling experiments. We introduce the different strategies of human disease modeling including transdifferentiation, human embryonic stem (ES) cell-based models, iPS cell-based models and genome editing options. Analysis of disease-relevant phenotypes is discussed. In more detail, we provide exemplary insight into modeling of the neurodevelopmental defects in autism spectrum disorder (ASD) and the process of neurodegeneration in Alzheimer’s disease (AD). Besides monogenic diseases, iPS cell-derived models also generated data from idiopathic and sporadic cases. |
| Databáze: | OpenAIRE |
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