First Synthesis of Methyl 2-Amino-6-Methoxynicotinate Using a Combination of Microwave and Flow Reaction Technologies

Autor:	Nader Fotouhi, T. Szommer, Tamas Meszaros, Dmytro Tymoshenko, Jozsef Kovacs, Paul Gillespie, Tamas Nagy, Agnieszka Kowalczyk, Gyorgy Jeges, Robert Alan Goodnow
Rok vydání:	2010
Předmět:	2-Pyridone chemistry.chemical_compound chemistry Organic Chemistry Regioselectivity Organic chemistry Amine gas treating Chemical synthesis Microwave
Zdroj:	Synlett. 2011:203-206
ISSN:	1437-2096 0936-5214
Popis:	The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, followed by microwave-induced reaction with p-methoxybenzylamine, and final deprotection under flow reaction hydrogenation conditions. Two key steps in the reported synthesis are a microwave-induced methoxylation and a microfluidic hydrogenation that afford improved regioselectivity and purity profile of the reaction products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::65b5af11463a8fa617e030aa2494dc72 https://doi.org/10.1055/s-0030-1259283 Zobrazit plný text záznamu