Radiolysis of DNA–protein complexes

Autor: Nathalie Gillard, Bertrand Castaing, Melanie Spotheim-Maurizot, Marie Běgusová, Michel Charlier, Denise Sy
Rok vydání: 2005
Předmět:
Zdroj: Radiation Physics and Chemistry. 72:265-270
ISSN: 0969-806X
DOI: 10.1016/j.radphyschem.2004.01.009
Popis: We discuss here modifications of DNA and protein radiolysis due to the interaction of these two partners in specific complexes. Experimental patterns of frank strand breaks (FSB) and alkali revealed breaks (ARB) obtained for DNA lac operator bound to the lac repressor and for a DNA containing an abasic site analog bound to the formamidopyrimidine-DNA glycosylase are reported. Experimental data are compared to predicted damage distribution obtained using the theoretical model RADACK.
Databáze: OpenAIRE