Abstract 084: Growth Stress And Cardiorenal Syndrome: Effect Of Renal Insufficiency On Blood Pressure And Cardiac Remodeling In Juvenile Rats
| Autor: | Alison J Kriegel, Chetan N Patil, Emma Schwasinger |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Hypertension. 79 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hyp.79.suppl_1.084 |
| Popis: | Pediatric patients living with chronic kidney disease (CKD) can experience many of the comorbidities associated with CKD in adults including hypertension and cardiovascular (CV) pathology, as well as impaired somatic growth. The goal of this study was to understand how CKD impacts blood pressure and cardiac remodeling during a period of rapid somatic growth. We hypothesized that renal insufficiency in juvenile rats would lead to both impaired growth and cardiac hypertrophy, demonstrating that it is an appropriate model for studying mechanisms of cardiorenal syndrome (CRS) in pediatric patients. Young male Sprague Dawley rats (4-5 weeks of age) were weighed and underwent nuclear magnetic resonance imaging to assess body mass and composition and were then randomized to naïve (n=6), Sham (n=9) or 5/6 nephrectomy (5/6Nx; n=11) groups. Rats underwent echocardiography before surgery and at the end of the 4 week study. Anesthetized blood pressure was measured via the carotid artery. Tissues were collected weighed and stored for histological and molecular analysis. Results presented as mean±SEM, one-way ANOVA and p |
| Databáze: | OpenAIRE |
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