Adipocytokines, growth factors and oxidative markers programmed Alterations in intrauterine growth retardation offspring rats with relevance of melatonin
| Autor: | Omyma Galal Ahmed, Eman A Negm |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Fetus business.industry Offspring General Chemical Engineering Adipokine Intrauterine growth restriction medicine.disease Nitric oxide Melatonin chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Placenta medicine Ghrelin business reproductive and urinary physiology medicine.drug |
| Zdroj: | Bulletin of Egyptian Society for Physiological Sciences. 32:223-244 |
| ISSN: | 2356-9514 |
| DOI: | 10.21608/besps.2012.35864 |
| Popis: | Background: Intrauterine growth restriction (IUGR) is an important perinatalproblem that poses several serious short- and long-term adverse effects on health.Lead is a common environmental and industrial pollutant. Although, a variety ofunfavorable effects of lead may be concerned; the knowledge about its negativedevelopmental effects and its pathophysiological mechanisms remain uncertain. Thisstudy aimed to verify the role of adipocytokines, oxidative markers and growth factorsprogrammed alterations in pathophysiology of IUGR induced by lead in albino ratsalso; to investigate the potential role of melatonin or continuous light or darkness asprophylactic against IUGR. Methods: All pregnant rats except two control groups(saline and melatonin) were given lead in drinking water throughout the pregnancy.Some pregnant rats were co-administered 10 mg/kg melatonin SC while, others wereexposed to lead simultaneously with continuous darkness or light. Half of dams ineach group were delivered spontaneously for following up their weight, pups weights(BW), crown-rump and tail lengths and pups survival rate after 21 days (PND21).The other half of the dams were delivered by laparotomy for detection of placentaweight and lead concentration in placenta. Results: As expected, exposure to leadresulted in decreasing all physical characters of fetus at PND 0 and 21. Of interest,melatonin supplementation or continuous darkness throughout the pregnancyameliorated lead-induced IUGR characters. The counterbalance role of melatoninmay be mediated by a significant adjustment of lead-induced alternations in the levelsof adipocytokines (TNF-a, IL-6 and ghrelin) and growth factors (platelet-derivedgrowth factor, placental growth hormone, transforming growth factor-a and insulingrowth factor-1), nitric oxide and oxidative markers. Therefore, melatonin or itsstimulator may represent a therapeutic option for IUGR and other perinatalcomplications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|