Determination of the Agglutination Reactions Using Power Spectral Analysis of the Depolarized Light Intensity Fluctuations Scattered from Magnetic Particles

Autor:	Akihiro Namba, Toshimitsu Musha, Yoshinori Yaginuma
Rok vydání:	1991
Předmět:	Range (particle radiation) Chemistry General Engineering Analytical chemistry General Physics and Astronomy Spectral density Magnetic particle inspection Electrolyte equipment and supplies Light scattering Magnetic field Light intensity Magnetic nanoparticles Atomic physics human activities
Zdroj:	Japanese Journal of Applied Physics. 30:1901
ISSN:	1347-4065 0021-4922
DOI:	10.1143/jjap.30.1901
Popis:	Presented here is a new optical method for evaluating the agglutination reactions of magnetic particles. Light intensity fluctuations scattered from the particles are detected by a cross-polarized optical measurement system. As soon as the electrolyte (NaCl)-induced coagulation of 2 min in a uniform magnetic field is completed, the sample data are gathered under the influence of a half-wave rectified magnetic field. The power spectral density has a strong peak at the frequency of the applied magnetic field. The spectral peak significantly increases by more than 103 with the NaCl concentration in the range between 0.03 and 0.1 mol/l. Furthermore, a sensitive immunoassay by means of magnetic particles can be achieved in a short-time measurement without any complex procedures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64de6092cdda887574ced123cb890de3 https://doi.org/10.1143/jjap.30.1901 Zobrazit plný text záznamu