Lutein-loaded lipid-core nanocapsules: Physicochemical characterization and stability evaluation
| Autor: | Tania Maria Haas Costa, Alessandro de Oliveira Rios, Aelson Aloir Santana Brum, Priscilla Pereira dos Santos, Adriana Raffin Pohlmann, Karina Paese, André Jablonski, Médelin Marques da Silva, Silvia Stanisçuaski Guterres, Simone Hickmann Flôres |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
endocrine system Lutein Chromatography Dispersity food and beverages 04 agricultural and veterinary sciences 02 engineering and technology Polymer 021001 nanoscience & nanotechnology 040401 food science eye diseases Nanocapsules chemistry.chemical_compound 0404 agricultural biotechnology Colloid and Surface Chemistry chemistry Zeta potential sense organs Solubility 0210 nano-technology Lipid core Tetrahydrofuran |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 522:477-484 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2017.03.041 |
| Popis: | Lutein nanocapsules (Lutein-LNC) were developed by the technique of interfacial deposition of the preformed polymer poly-e-caprolactone (PCL). The lutein crystals were obtained from Marigold flowers by exhaustive extraction using tetrahydrofuran to the obtention of lutein 92% pure. The nanocapsules were prepared, characterized and their stability investigated. The results showed monomodal size distribution with a polydispersity index of 0.11 ± 0.02, z -average of 191.9 ± 3.24 nm, zeta potential of −5.14 ± 2.22 mV and encapsulation efficiency of 99.51%. The physicochemical properties of polymeric nanocapsules suspension were evaluated in function of storage time to determine the formulation stability. After 60 days of storage (4 °C), the Lutein-LNC were stable without significant changes in diameter and color (p ≥ 0.05); and residual content of lutein was 36% relative to initial value. However, Lutein-LNC stored at 25 °C presented changes in zeta potential, pH, color values and residual content over time when compared to nanocapsules stored at 4 °C. Lutein content in the nanocapsules after 90 days of storage at 4 °C and 25 °C presented superior values than free lutein after 30 days of storage in same conditions. Thus, the nanoencapsulation allowed the solubilization of lutein in the aqueous medium and increased the stability of lutein in different temperatures. |
| Databáze: | OpenAIRE |
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