AB0086 PREGNANCY OUTCOMES IN SYSTEMIC LUPUS ERYTEMATOSUS (SLE)
| Autor: | Zemfira Alekberova, Regina Goloeva, Tatiana Popkova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Obstetrics business.industry Cumulative dose Incidence (epidemiology) media_common.quotation_subject Immunology Endometriosis Fertility medicine.disease General Biochemistry Genetics and Molecular Biology Rheumatology Dysplasia medicine Coagulopathy Immunology and Allergy Sex organ business media_common |
| Zdroj: | Annals of the Rheumatic Diseases. 80:1072.3-1073 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2021-eular.3424 |
| Popis: | Background:There’s no doubt that SLE has negative effect not only on the course of pregnancy, but also on maternal and fetal outcomes.Objectives:To clarify pregnancy outcomes in patients with SLE by means of retrospective analysis.Methods:The study group included 12 women with SLE aged 20-40 years, and the control group - 15 age-matching healthy women. SLE diagnosis was established based on the EULAR/ACR classification criteria, 2019. The SLEDAI 2K was used to evaluate disease activity, and the SLICC index – to evaluate damage. Completed by all women issue-specific questionnaire covered clinical symptoms of SLE and details of obstetric history (characteristics of menstrual and reproductive function, presence of genital and extragenital pathology, previous pregnancies outcomes; previous intrauterine interventions, a history of coagulopathy).Results:SLE patients’ mean age was 33.5 [29;38] years, and control group subjects’ - 32.0 [26;35] years. Mean disease duration was 11.5 [2.8;18] years. Acute, subacute and chronic SLE was established in 33%, 17%, and 50%, respectively. Disease activity according to SLEDAI 2K was low in 25%, moderate – in 33%, and high – in 42% of pts. The SLICC damage baseline evaluation: no damage – 17%, low – 50%, medium – 16.5%, high-16.5%. Past pregnancies were documented in 7 out of 12 SLE patients and 6 healthy subjects from the control group.Table 1.Pregnancy outcomesPregnancy, nSLE, n=16Control, n=15pBirth9 (56,3%)13 (87%)0,00Abortion2 (12,5%)00,00Unfavorable pregnancy outcome5 (31,2%)2 (13%)0,00Missed miscarriage4 (25%)00,00Spontaneous abortion1 (6%)2 (13%)nsSpontaneous vaginal delivery of a full-term baby was documented in both groups. Unfavorable pregnancy outcomes were significantly more frequent in SLE pts (31% vs 13% in the control group, p= 0.001). Two SLE pts after cyclophosphane therapy (10.6 and 18.4 g cumulative dose) and low AMH levels (< 1 ng/ml) failed to become pregnant, although never used contraception.Analysis of gynecological history indicate that episodes of menstrual disorders were significantly more often reported in SLE pts (50% vs 20% in controls, p=0.001), similarly, gynecological diseases were also documented in 50% of SLE pts (chronic salpyngo-oophoritis, colpitis, endometriosis and uterine endometrioma, subserous uterine myoma, cervical dysplasia, cervical erosion), meanwhile low AMH was found only in 4 SLE pts; there was only 1 subject with gynecological condition – teratoma of the ovaries – in the control group (favorable outcome – surgical removal, preserved fertility and two births after surgery).Conclusion:The incidence of unfavorable pregnancy outcomes is significantly higher in patients with SLE compared to the control group of healthy women.Disclosure of Interests:None declared |
| Databáze: | OpenAIRE |
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