Treatment of pituitary dwarfism in children and teenagers in the Stavropol territory
| Autor: | Svetlana Dolbnya, Tatyana A. Uglova, Lilit Samvelovna Alaverdyan, Elena Otarievna Demurcheva, Tatyana Boleslavovna Semenova, Rafael Isaakovich Arakelyan, Marina Stoyan, Elena Semenovna Slavickaya, Viktoria Alexandrovna Kuryaninovna, Leonid Klimov, Tatyana M. Vdovina, Roza Atanesyan |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Somatotropic cell business.industry Endocrinology Diabetes and Metabolism Pituitary dwarfism Physiology Anthropometry medicine.disease Predictive factor Growth hormone deficiency Endocrinology Internal medicine Blood cholesterol Medicine In patient business Recombinant growth hormone |
| Zdroj: | Problems of Endocrinology. 62:10-15 |
| ISSN: | 2308-1430 0375-9660 |
| DOI: | 10.14341/probl201662110-15 |
| Popis: | The article is devoted to the analysis of clinical and anthropometric indicators of 38 children and adolescents with pituitary dwarfism in the Stavropol region, receiving replacement therapy with recombinant growth hormone (rGH). The authors demonstrated a high growth stimulating efficacy of the rGR, as well as a positive impact on the level of blood cholesterol in children with somatotropic deficiency. Prognostic factors influencing the effectiveness of treatment were found (chronological age of initiation of therapy, baseline SDS of growth). In particular, it is shown that therapy with preparations of GH in children aged 8 to 10 years allows you to achieve a higher growth-stimulating effect in comparison with patients whose treatment is carried out at a later age. The study of the relationship between the initial deviation of the length of the body and the results of therapy in patients with growth hormone deficiency illustrates that a pronounced lag in growth is a predictive factor provides a more significant effect drugs rGR. |
| Databáze: | OpenAIRE |
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