PHARMACOLOGICAL ANALYSIS OF THE MECHANISMS OF ACTION OF A OUINOXALINE DERIVATIVE WITH ANXIOLYTIC PROPERTIES
| Autor: | M. O Skripka, D. V Maltsev, A. A Spasov, M. A Perfiliev |
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| Rok vydání: | 2022 |
| Zdroj: | Journal of Volgograd State Medical University. 19:134-140 |
| ISSN: | 1994-9499 1994-9480 |
| DOI: | 10.19163/1994-9480-2022-19-3-134-140 |
| Popis: | The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction of the compound with dopaminergic (catalepsy, induced with haloperidol), adrenergic (clonidine hypothermia), GABAergic (test of interaction with flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that the ZDM-81 compound is able to prolong and potentiate the effects of 5-hydroxytryptophan, reduces catalepsy caused by haloperidol, does not affect the hypothermic effect of clonidine, and the effect of the ZDM-81 compound is blocked by flumazenil. Thus, for the studied substance, a serotonergic, GABAergic, and weak dopaminergic pathway for the realization of the action was shown, which requires further research. |
| Databáze: | OpenAIRE |
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