Biphasic stimulant and sedative effects of ethanol
| Autor: | Dana H. Bovbjerg, Joel Erblich, Mitchell Earleywine, Bryna Erblich |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Ethanol
medicine.drug_class medicine.medical_treatment Sedation Medicine (miscellaneous) Alcohol Stimulation Toxicology Stimulant Psychiatry and Mental health Clinical Psychology chemistry.chemical_compound chemistry Sedative Decreased Sensitivity Anesthesia medicine Sedative Effects medicine.symptom Psychology |
| Zdroj: | Addictive Behaviors. 28:1129-1139 |
| ISSN: | 0306-4603 |
| DOI: | 10.1016/s0306-4603(02)00221-6 |
| Popis: | Children of alcoholics (COAs) have an increased risk of developing alcoholism themselves. The mechanisms responsible are not yet known. One compelling theory postulates that COAs may have an increased sensitivity to the stimulant effects of alcohol during the ascending limb of the blood alcohol curve combined with a decreased sensitivity to the putatively undesirable sedative effects of the drug during the descending limb, providing a particularly strong motivation to drink. Consistent with this theory, we hypothesized that compared to children of nonalcoholics (CONAs), COAs would display higher levels of ascending limb stimulation and lower levels of descending limb sedation. In the present study, 100 college students, who were either COAs (n=18) or CONAs (n=82), completed the Biphasic Alcohol Effects Scale (a self-report measure of stimulation and sedation): (1) before consuming 0.85n ml/kg ethanol; (2) during the ascending limb of their BAC, and; (3) during the descending limb of their BAC. Although findings indicated that COAs and CONAs had comparable levels of sedation at each time point, a significant GroupxTime interaction (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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