On the facile dehydrohalogenation of amino acid derived chloromethyl ketones

Autor:	N.G. Delaney, Jelka Pluščec, Eric M. Gordon, J. Sundeen, Sesha I Natarajan
Rok vydání:	1984
Předmět:	chemistry.chemical_classification Reaction mechanism Bicyclic molecule Organic Chemistry Biochemistry Haloketone Amino acid chemistry.chemical_compound chemistry Basic solution Drug Discovery Lactam Dehydrohalogenation Organic chemistry Aliphatic compound
Zdroj:	Tetrahedron Letters. 25:3277-3280
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)81363-0
Popis:	Amino acid derived chloromethyl ketones are shown to undergo a general dehydrohalogenation reaction under mild, basic, nonnucleophilic conditions to afford α-β-unsaturated ketones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::630c97f442db68aa65d1b7353d90721e https://doi.org/10.1016/s0040-4039(01)81363-0 Zobrazit plný text záznamu