Efficacy of 5-fluorouracil on Tumor Growth in Walker -256 Xenografted rat? Mice is dependent on Circadian Rhythm
| Autor: | Tadahiko Sato, Hiroshi Sakuma, Seiichi Takenoshita, Yoshihisa Koyama, Morihiro Tsuda, Motoki Sassa, Yasuhide Kofunato, Takashi Ohshima, Hidekazu Sugeno, Hideko Imaizumi, Chiyo Okouchi, Yohei Watanabe, Nobuhiro Yoshimoto, Teruhide Ishigame, Wataru Sakamoto, Hisashi Onozawa, Shoutaro Fujita, Yuji Takebayashi, Masami Hoshino, Tomoyuki Monnma, Masaru Saitou |
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| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
education.field_of_study Chemotherapy medicine.medical_specialty Angiogenesis business.industry medicine.medical_treatment Chronotherapy (sleep phase) Population Pharmacology Endocrinology Oncology Fluorouracil Internal medicine medicine Immunohistochemistry Pharmacology (medical) Circadian rhythm education business Microvessel medicine.drug |
| Zdroj: | Annals of Cancer Research and Therapy. 18:43-46 |
| ISSN: | 1880-5469 1344-6835 |
| Popis: | Chronotherapy is one of the most active treatment schedule, based on the adjustment of drug delivery to the 24-hour rhythms generated by circadian rhythm. The aim of this study is to confirm that the efficacy of 5-fluorouracil (5-FU) is dependent on circadian rhythm, using Walker-256 xenografted rat. The present study demonstrated that tumor developed more rapidly at night rather than at day. Moreover, the administration of 5-FU at night was more effective rather than that at day. Furthermore, the microvessel count by immunohistochemical staining of endothelial cells revearled that tumors treated with 5-FU at night contained significantly less microvessels than those at day. In conclusion, our present data suggested that chronotherapy would contribute to the improvement of chemotherapy in patients with some population of malignancy through the control of angiogenesis. |
| Databáze: | OpenAIRE |
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