Prolonged survival of a 7‐year‐old vizsla with histiocytic sarcoma affecting the spinal cord and protein‐losing nephropathy after lomustine treatment
| Autor: | Marco Rosati, Nicki Reed, Ivona Orgonikova, Viktor Palus, Simon Tappin |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Pathology Chemotherapy General Veterinary 040301 veterinary sciences business.industry medicine.medical_treatment 04 agricultural and veterinary sciences Lomustine Histiocytic sarcoma medicine.disease Spinal cord Nephropathy Vertebra 0403 veterinary science 03 medical and health sciences Lumbar medicine.anatomical_structure medicine Histopathology business 030304 developmental biology medicine.drug |
| Zdroj: | Veterinary Record Case Reports. 8 |
| ISSN: | 2052-6121 |
| DOI: | 10.1136/vetreccr-2019-000994 |
| Popis: | A 7-year-old male entire vizsla, diagnosed with protein-losing nephropathy (PLN) one month previously, presented with lumbar hyperaesthesia. MRI of the lumbar spine revealed an extradural mass at the level of L3 vertebra. Most of the mass was surgically excised during left-sided pediculectomy at L3 and left-sided L2-L3 mini-hemilaminectomy. Histopathology revealed a moderately proliferative, lymphocyte/plasmacyte-rich, mesenchymo-invasive localised histiocytic sarcoma affecting the spinal cord. Chemotherapy with lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosurea) was commenced for treatment of the histiocytic sarcoma and during therapy the persistent proteinuria resolved, having previously only shown an improvement with symptomatic treatment. The dog survived 881 days after diagnosis, which is exceptional in cases of histiocytic sarcomas affecting CNS. |
| Databáze: | OpenAIRE |
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