Contact-Tracing Outcomes Among Household Contacts of Fully Vaccinated Coronavirus Disease 2019 (COVID-19) Patients: San Francisco, California, 29 January–2 July 2021

Autor: Darpun D Sachdev, Rilene Chew Ng, Madeline Sankaran, Alexandra Ernst, Katherine T Hernandez, Venice Servellita, Alicia Sotomayor-Gonzalez, Juliet Stoltey, Stephanie E Cohen, Trang Quyen Nguyen, Charles Y Chiu, Susan Philip
Rok vydání: 2021
Předmět:
Zdroj: Clinical Infectious Diseases. 75:e267-e275
ISSN: 1537-6591
1058-4838
DOI: 10.1093/cid/ciab1042
Popis: Background The extent to which vaccinated persons diagnosed with coronavirus disease 2019 (COVID-19) can transmit to other vaccinated and unvaccinated persons is unclear. Methods Using data from the San Francisco Department of Public Health, this report describes outcomes of household contact tracing during 29 January–2 July 2021, where fully vaccinated patients with COVID-19 were the index case in the household. Results Among 248 fully vaccinated patients with breakthrough infections, 203 (82%) were symptomatic and 105 were identified as the index patient within their household. Among 179 named household contacts, 71 (40%) contacts tested, over half (56%) were fully vaccinated and the secondary attack rate was 28%. Overall transmission from a symptomatic fully vaccinated patient with breakthrough infection to household contacts was suspected in 14 of 105 (13%) of households. Viral genomic sequencing of samples from 44% of fully vaccinated patients showed that 82% of those sequenced were infected by a variant of concern or interest and 77% by a variant carrying mutation(s) associated with resistance to neutralizing antibodies. Conclusions Transmission from fully vaccinated symptomatic index patients to vaccinated and unvaccinated household contacts can occur. Indoor face masking and timely testing of all household contacts should be considered when a household member receives a positive test result in order to identify and interrupt transmission chains.
Databáze: OpenAIRE
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