Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity
| Autor: | Utpal Kumar Karmakar, Thaworn Kowithayakorn, Takashi Koyano, Masami Ishibashi, Midori A. Arai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Tumor cells biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Boesenbergia 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Drug Discovery Cancer cell Trail resistance |
| Zdroj: | Tetrahedron Letters. 58:3838-3841 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.08.055 |
| Popis: | TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL - resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three ( 1 – 3 ) new isopimarane diterpenes, boesenberols I–K, together with two ( 4 – 5 ) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity. |
| Databáze: | OpenAIRE |
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